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Turkish Journal of Physical Medicine and Rehabilitation
2021 , Vol 67 , Num 4
Pregabalin as a probable cause of central serous chorioretinopathy: Two case reports
2 Department of Physical Medicine and Rehabilitation, Yeditepe University Hospital, Istanbul, Turkey
3 Department of Ophthalmology, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey
4 Department of Physical Medicine and Rehabilitation, University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey DOI : 10.5606/tftrd.2021.5433 Pregabalin is commonly used for the treatment of neuropathic pain and is attributed to adverse effects of peripheral vasodilation and peripheral edema. Central serous chorioretinopathy (CSCR) is characterized by choroidal fluid leaks from choroidal vessels under the retina, causing focal retinal detachment with macular vision loss. Herein, we report two cases admitted to our clinic with vision loss while under pregabalin treatment. Upon eye examination, both patients were diagnosed with acute CSCR. Pregabalin treatment was discontinued upon the diagnosis of CSCR. We consider that the use of pregabalin in the presented two cases may be the causal effect of the CSCR diagnosis, as pathophysiology of CSCR is in parallel with the edema-related adverse effects of pregabalin. Keywords : Adverse drug reaction, central serous chorioretinopathy, pregabalin