Serum netrin-1 and netrin receptor levels in fibromyalgia and osteoarthritis
2 Department of Physical Medicine and Rehabilitation, Fırat University Faculty of Medicine, Elazığ, Türkiye
3 Department of Biochemistry, Fırat University Faculty of Medicine, Elazığ, Türkiye
4 Department of Internal Medicine, Division of Rheumatology, Fırat University Faculty of Medicine, Elazığ, Türkiye DOI : 10.5606/tftrd.2022.8114 Objectives: This study aims to define serum levels of netrin-1 and netrin receptors in patients with fibromyalgia (FM) and osteoarthritis (OA).
Patients and methods: This cross-sectional study was conducted with a total of 150 female participants (mean age: 47.2±16.1 years; range, 18 to 89 years) at Fırat University between June 2016 and December 2016. The participants were evaluated in three groups: the FM group with 50 patients, the OA group with 50 patients, and the control group, which included 50 healthy volunteers. Netrin-1, netrin receptors (DCC, UNC5B, and UNC5D), interleukin (IL)-6, IL-10, and IL-17 levels were analyzed by the enzyme-linked immunosorbent assay from the serum samples of the participants.
Results: The level of serum netrin-1 was significantly lower in the FM group than in the control and OA groups (p<0.01 and p<0.001, respectively). However, the difference between patients with OA and healthy controls in terms of netrin-1 was not statistically significant (p>0.05). In addition, serum levels of netrin receptors and cytokines in the FM group were similar to the control group (p>0.05). However, serum DCC, UNC5D, IL-6, and IL-10 levels were higher in the OA group compared to the control group (p<0.001, p<0.05, p<0.01, and p<0.001, respectively).
Conclusion: Serum netrin-1 level is suppressed in FM, which suggests that netrin-1 is influential in FM pathogenesis.
Keywords : Cytokine, fibromyalgia, netrin-1, osteoarthritis